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- www.worldgastroenterology.com/guideline-ibs/irritable-bowel-sindrome-ibs-russian.
- Longstreth G. F., Wilson A., Knight K. et al. Irritable bowel
syndrome, health care use, and costs: a U. S. managed care perspective // Am J
Gastroenterol. 2003; 98: 600607.
- www.worldgastroenterology.com/guideline-ibs/irritable-bowel-sindrome-ibs-english.
- Drossman D. A. The Functional Gastrointestinal Disorders and the
Rome III Process // Gastroenterology. 2006; 130 (5): 13771390.
- Lembo T., Naliboff B., Munakata J. et. al. Symptoms and visceral
perception in patients with pain-predominant irritable bowel syndrome // Am J
Gastroenterol. 1999; 94: 13201326.
- Cummings J. Y., Rombeau J. L., Sakata T. (eds). Physiological and
Clinical Aspects of Short-Chain Fatty Acids. Cambridge University Press. 2004.
596 p.
- Hu S., Dong T. S., Dalai S. R., Wu F., Bissonnette M., Rwon J. H.
et al. The microbe derived short chain fatty acid butyrate targets
miRNA-dependent p21 gene expression in human colon cancer // PLoS ONE. 2011; 6
(1): 16221.
- Cherbut C. Lactulose and colonic motility // Annales de
Gastroenterologie et dHepatologie. 1998; 34 (2): 8594.
- Cherbut C., Aube A. C., Blottiere H. M., Galmiche J. P. Effects
of short-chain fatty acids on gastrointestinal motility // Scand. J.
Gastroenterology. 1997; 32 (Supp. 222): 5861.
- Nieuwenhuijs V. B., Verheem A., Van
Duijvenbode-Beumer H. et al. The role of interdigestive small bowel
motility in the regulation of gut micro? ora, bacterial overgrowth, and
bacterial translocation in rats // Annals of Surgery. 1998; 228 (2): 188193.
- . . :
[]. .:
. 2014. . 64.
- Canani R. B., Di Costanzo M., Leone L., Pedata M., Meli R., Calignano
A. Potential benecial effects of butyrate in intestinal and
extraintestinal diseases // World J Gastroenterol. 2011; 17 (12): 15191528.
- MacFabe D. F. Short-chain fatty acid fermentation products of the
gut microbiome: implications in autism spectrum disorders // Microb Ecol.
Health Dis. 2012; 23. DOI: 10.3402/mehd.v23 i0.19260.
- Soret R., Chevalier J., De Coppet P. et al. Short-chain fatty
acids regulate the enteric neurons and control gastrointestinal motility in
rats // Gastroenterology. 2010; 138 (5): 17721782.
- Tazoe H., Otomo Y., Kaji I. et al. Roles of short-chain fatty
acids receptors GPR41 and GPR43 on colonic functions // J Physiol Pharmacol.
2008; 59 (Suppl 2.): 251262.
- Kilkens T. O., Honig A., van Nieuwenhoven M. A., Riedel W. J., Brummer
R. J. Acute tryptophan depletion affects braingut responses in irritable
bowel syndrome patients and controls // Gut. 2004; 53 (12): 17941800.
- Vahoutvin S. A., Troost F. J., Kilkens T. O. et al. The effects
of butyrate enemas on visceral perception in healthy volunteers //
Neurogastroenterol Motil. 2009; 21 (9): 952-e76.
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