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Спутники
РН
SpaceX
Роскосмос
NASA
СпутникиРНSpaceXРоскосмосNASAPublication date: 30 July 2026
Source: Journal of Biomimetics, Biomaterials and Biomedical Engineering Vol. 73
Author(s): Tetiana Vislohuzova, Rita Rozhnova, Tetiana Kiselova, Galyna Kozlova
This study investigates the biodegradability of composite materials containing dacarbazine (DAC), synthesized from hydrophilic polyurethane-ureas (PUUs) incorporating fragments of 4,4′-diaminodiphenylmethane (DADPh) and a poly(vinyl alcohol)-poly(ethylene glycol) (PVA-PEG) graft copolymer under simulated inflammatory conditions mimicking blood contact. Biodegradability was assessed using Fourier-transform infrared (FTIR) spectroscopy, tensile testing, differential scanning calorimetry (DSC), and Transmission Optical Microscopy (TOM) by analyzing changes in the structural, mechanical, thermophysical properties, and composite surface morphology after 1, 3, and 6 months of incubation in Fenton’s reagent. The results revealed that DAC-containing composites undergo surface structural rearrangements characterized by alterations in hydrogen bonding and partial cleavage of chemical bonds under oxidative conditions. These findings confirm that PUU-based DAC composites containing DADPh and PVA-PEG fragments are susceptible to oxidative degradation in Fenton’s reagent. The biodegradability of these materials ensures controlled DAC release during progressive polymer matrix degradation, highlighting their potential as temporary implantable systems for localized delivery of the antitumor agent DAC.
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