Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care. Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based treatments for acute bronchiolitis in hospitalized children are few and guidelines largely recommend against most interventions. In this issue of JAMA, Baudin and colleagues for the PROPOSITIS Investigators evaluated a promising but understudied option: prone positioning. In a well-designed randomized clinical trial (RCT) conducted from 2021 to 2023, the authors enrolled 451 infants younger than 6 months with viral bronchiolitis who were receiving high-flow nasal cannula (HFNC) support. The primary end point of the study was escalation of care to noninvasive or invasive positive pressure ventilation (notably, only 3 children in the cohort were intubated). The primary intention-to-treat analysis did not reach statistical significance—with an odds ratio for escalation with prone positioning of 0.66 (95% CI, 0.40-1.07)—which was surprising given that their pilot physiological study suggested that prone positioning either improves effort of breathing or has negligible impact.
| # | Наименование новости | Тональность | Информативность | Дата публикации |
|---|---|---|---|---|
| 1 | Kind nach Unfall in Krankenhaus | 0 | 5 | 30-06-2026 |
| 2 | Modeling Oxygen Saturation Targets, Mortality, and Retinopathy in Preterm Infants | 0 | 7.78 | 21-07-2026 |
| 3 | В Петербурге нашли истощенного младенца | 0 | 0 | 13-09-2018 |
| 4 | Свисток в бронхах едва ни убил ребёнка во время игры | -2 | 6 | 13-07-2026 |
| 5 | Эксперт сообщил, что постковидный синдром у детей фиксируется в 10-30% случаев | 0 | 0 | 09-02-2022 |
| 6 | Не пациент на УЗИ, а УЗИ к пациенту: в Сеченовском Университете обсудили новый метод проведения ультразвукового исследования | 0 | 5 | 19-06-2026 |
| 7 | Эксперт заявила, что постковидный синдром встречается и у бессимптомно переболевших детей | 0 | 0 | 02-11-2021 |
| 8 | Не игнорируйте симптомы: пульмонолог Марина Виноградова о лечении гриппа у детей | 0 | 18.58 | 11-02-2026 |
| 9 | Неонатологи — не волшебники, хотя... О первом в России ковидном госпитале для младенцев | 0 | 0 | 19-07-2021 |