Trinuclear Heptamethine Dyes for Shortwave Infrared In Vivo Imaging

Дата публикации: 07-10-2026 00:00:00

ABSTRACT The term polymethine dye (PMD) has been intimately connected to the dinuclear scaffold–two heterocycles linked together by a polymethine chain of varying length. Dinuclear PMDs have been a successful scaffold for noninvasive in vivo imaging in the biologically advantageous near infrared (NIR) and shortwave infrared (SWIR) regions of the electromagnetic spectrum. Trinuclear PMDs, resulting from the addition of a third heterocycle into the polymethine chain, possess the same photophysical properties that make dinuclear dyes excellent fluorescent probes, but have yet to be investigated for in vivo imaging. Herein, we expand upon the dinuclear and trinuclear heptamethine dye scaffolds by taking advantage of the increased reactivity of a cyclopentenyl linker and synthesizing flavylium‐ and chromenylium‐based SWIR‐emitting fluorophores. The trinuclear scaffold instills the fluorophores with increased steric bulk, leading to beneficial photophysical properties in micelles and...

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