MILWAUKEE — William Contreras hit a tiebreaking homer in the seventh inning and the Milwaukee Brewers hung on to beat San Diego 3-2 in their NL Division Series opener Saturday night after a potential go-ahead homer by the Padres’ Ty France hit the American Family Field roof and landed in outfielder Jackson Chourio’s glove for an out.

San Diego had a runner on first with one out in the ninth inning when France hit a towering flyball that struck a railing on the roof before Chourio caught it in fair territory on the left-field warning track.

Under the stadium’s ground rules, any batted ball striking the roof or one of its cables in fair territory is a fair ball that can be caught for an out, so Chourio’s catch retired France. The Padres unsuccessfully challenged that France’s drive was a foul ball.

Jackson Merrill then lined out to right to end the game.

Chourio also hit a two-run homer as the Brewers won for the 16th time in 19 games. San Diego lost for only the fourth time in its last 24 outings despite chasing Milwaukee ace Jacob Misiorowski after four innings.

This best-of-five series continues Sunday with a Game 2 pitching matchup featuring San Diego’s Michael King (12-10, 3.21 ERA) and Milwaukee’s Logan Henderson (11-3, 2.47).

Contreras had gone just 1 for 20 against the Padres this season before delivering the biggest hit of the game on a 3-2 pitch from Adrian Morejon. As his 406-foot shot cleared the wall in right-center field, the three-time All-Star turned to face Milwaukee’s dugout and celebrate in front of teammates on his way to first base.

Contreras joined Boston’s Willson Contreras to become the fifth set of brothers to homer in the same postseason, according to the Elias Sports Bureau. The others are Ken and Clete Boyer (1964), Sandy Jr. and Roberto Alomar (1997), Stephen and J.D. Drew (2007) and Bo and Josh Naylor (2025). Willson Contreras homered in Game 2 of Boston’s AL Wild Card Series loss to the New York Yankees.

San Diego wasted scoring opportunities all night, particularly late in the game.

San Diego first baseman Ty France discusses a play where the his long ball to left field that appeared to be going for a ninth-inning homer was instead caught in left field by Jackson Churio in the Brewers’ 3-2 win over the Padres in Game 1 of the NLDS in Milwaukee. IMAGN IMAGES via Reuters Connect

The Padres loaded the bases in the seventh against Abner Uribe before DL Hall retired Merrill on a fly to left to end the threat.

San Diego also put runners on first and second with one out in the eighth after Hall issued a pair of walks, but the Padres again failed to capitalize. Austin Hays hit a fly to right against Hall that advanced pinch-runner Samad Taylor to third, then Trevor Megill struck out Fernando Tatis Jr. on three pitches to strand runners on the corners.

Megill then worked around a leadoff single to Dustin Harris in the ninth to pick up the save while getting a major assist from the roof.

Jackson Chourio catches a ball that deflected off of the roof hit by Ty France that appeared to be headed over the wall in the ninth inning of the Brewers’ Game 1 win over the Padres. Getty Images

Milwaukee was opening its postseason Saturday after winning a franchise-record 103 games to earn home-field advantage throughout the playoffs. Misiorowski played a big role in that success by posting a 1.80 ERA, striking out 252 batters and limiting hitters to a .157 batting average to lead the major leagues in all three categories.

Misiorowski opened his first playoff start by throwing a 104.8 mph strike to Tatis, the fastest postseason pitch since tracking began in 2008.

But the 6-foot-7 right-hander left the game earlier than usual as the Padres fouled off 30 of his 88 pitches — 31 if you count Xander Bogaerts’ popup that was caught in foul territory.

Ty France reacts in frustration after he his long foul ball hit a rafter on the roof and was caught for an out during the ninth inning of the Padres’ Game 1 loss to the Brewers. AP Photo/Chris Carlson

San Diego took a 2-0 lead by scoring a pair of runs off Misiorowski in the second inning.

Bogaerts, Ethan Salas and Luis Campusano hit consecutive one-out singles, with Campusano’s base hit to right driving in Bogaerts. Jake Cronenworth then hit a broken-bat grounder, and first baseman Jake Bauers was unable to throw out Salas at the plate.

San Diego could have done even more damage that inning, but Manny Machado grounded out to leave the bases loaded.

Umpires discuss a long ball hit off of the roof by Ty France during the ninth inning of the Brewers’ Game 1 win over the Padres. France was ruled out on the play. Getty Images

The Brewers responded in the third thanks to Chourio, who already has established himself as one of the game’s top playoff performers at age 22.

With a runner on second and one out, Chourio delivered a 420-foot drive over the wall in left-center for his franchise-record fifth career postseason homer in his 13th playoff game. Chourio had shared the mark with Prince Fielder and Orlando Arcia.

According to MLB.com, the only other players to hit five playoff homers before their 23rd birthday are Kyle Schwarber and Juan Soto.