Enhancing Guideline-Directed Medical Therapy at Discharge Through Collaborative Care: Evidence from the TIME-HF Cluster Randomized Controlled Trial [version 2; peer review: 1 approved, 1 approved with reservations]

Дата публикации: 11-09-2026 09:00:47

Background Nurse-led care supported by mobile health (mHealth) technologies offers a feasible strategy to strengthen heart failure (HF) management in resource-constrained settings. This study evaluated the impact of an mHealth-enabled, nurse-led collaborative care model on prescription of guideline-directed medical therapy (GDMT) at discharge among patients with heart failure with reduced ejection fraction (HFrEF) in India. Methods The TIME-HF study was a multicenter, open-label, cluster-randomized controlled trial conducted across 22 centers enrolling patients with HFrEF. Centers were randomized 1:1 to an intervention arm (11 centers; 755 patients) or enhanced usual care (11 centers; 752 patients). In the intervention arm, nurses used an mHealth application to review GDMT prescriptions and recommend treatment modifications to physicians. GDMT at discharge was assessed individually and using a composite score. Intervention effects were evaluated using multivariable mixed-effects logistic regression models. Results Participants were predominantly male (77.6%) with a mean age of 61.9 years (SD 12.1). Hypertension (56.1%), diabetes (62%), and chronic kidney disease (18.4%) were common comorbidities. Ischemic heart disease was the leading etiology (77.4%), and 48.8% were in NYHA class III/IV. Baseline characteristics were similar between groups. At discharge, 20% received all four GDMT components, with higher use in the intervention group than usual care (27% vs 13%, p 

Схожие новости

#	Наименование новости	Тональность	Информативность	Дата публикации
1	Improving Medication Safety in Chronic Kidney Disease Using Rule-Based and Artificial Intelligence–Based Clinical Decision Support Systems: A Systematic Review of Randomized Controlled Trials [version 2; peer review: 2 approved]	0	11.17	28-08-2026
2	Process evaluation protocol of a trial evaluating app-based post knee arthroplasty telerehabilitation strategy in India [version 3; peer review: 2 approved]	0	12.38	29-09-2026
3	Predictors of Acceptance of Smartphone Application among People with Hypertension in India: A Cross-Sectional Study [version 3; peer review: 2 approved]	0	8.98	09-09-2026
4	The Impact of Cardiac Rehabilitation on Psychosocial Factors, Functional Capacity, and Left Ventricular Function in Patients with Coronary Artery Disease: Systematic Review and Meta-Analysis [version 2; peer review: 2 approved, 2 approved with reservations]	0	7.17	25-06-2026
5	Process mapping of a collaborative quality improvement study to optimise the use of antibiotics in intensive care units in Argentina: a Pathfinder study [version 2; peer review: 1 approved]	0	6.83	22-09-2026
6	Understanding Antecedents and Attributes in the Context of Upward Referral for Obstetric Emergencies: A Grounded Theory Study [version 3; peer review: 2 approved]	0	7.34	02-03-2026
7	Microbial keratitis management through the lens of pharmacy attendants in Siraha district of Nepal: A study of knowledge, attitudes, and practices [version 1; peer review: awaiting peer review]	0	5.83	26-09-2026
8	Pomegranate Compound Improves Heart Function by up to 80% in Study, but Not a Cure	0	8	29-09-2026
9	Lipoprotein(a)-Lowering Medication Agent to Reduce Cardiovascular Events	0	12.34	25-09-2026
10	Effect of Add-on Integrated Yoga and Ayurveda Management on Clinical and Neurobiological Parameters in Multiple Sclerosis: A Randomized Controlled Trial Protocol [version 1; peer review: 1 approved with reservations]	0	11.1	04-09-2026

Классификация: Пресс-релизы. Схожих патентов: 0. Схожих новостей: 10. Тональность: 0. Информативность: 15.84. Источник: wellcomeopenresearch.org.