Mitochondrial Protein Complexes: A Single Amino Acid Can Jeopardize Their Stability

Дата публикации: 25-09-2026 10:56:00

A tiny processing step has far-reaching consequences for mitochondrial function: The removal of a single amino acid determines whether new proteins can assemble into stable complexes within these cellular powerhouses. This process is carried out by a specific enzyme that precisely trims the mitochondrial proteins at their beginning. If this step is missing, numerous protein complexes lose their stability. This shows a study conducted by a research team led by Prof. Dr. Nora Vögtle of Heidelberg University and Prof. Dr. Pitter Huesgen of the University of Freiburg. The scientists identified a previously unknown mechanism by which human cells stabilize their mitochondrial protein balance.

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