The study focused on patients who take PrEP, as this population is at higher risk for other STIs.
News brief
A San Francisco sexual health clinic significantly reduced rates of bacterial sexually transmitted
infections (STIs) among patients by preemptively prescribing the antibiotic doxycycline for use
after unprotected sex (DoxyPEP).
CC BY 2.5 / Wikipedia
The study, which appeared in the August edition of the journal Sexually Transmitted Infections, focused on patients who take pre-exposure prophylaxis (PrEP), a medication that protects HIV-negative people from contracting the virus.
People who take PrEP tend to be at greater risk of contracting bacterial STIs, and researchers found that, among these patients, DoxyPEP (post-exposure prophylaxis) reduced the rate of new infections by 58%.
While randomized clinical trials of DoxyPEP have produced similar results, this study was among the first to test the intervention in a real-world setting.
Big success reducing syphilis, chlamydia, but not gonorrheaAll PrEP clients at the San Francisco AIDS Foundation Sexual Health Clinic have quarterly HIV and bacterial STI screening. As part of that routine care, the clinic began offering DoxyPEP to anyone who takes PrEP in November 2022. DoxyPEP is prescribed for use within 72 hours of unprotected sex.
Among the 1,209 PrEP patients who opted to take DoxyPEP, there was a 78% reduction of syphilis cases and a 67% reduction in chlamydia.
Interestingly, the study found no significant decline in gonorrhea. Researchers theorize that
might be because the prophylactic window for this bacterial infection is smaller, with patients
needing to take doxycycline in less than 24 hours after condomless sex. Other studies have suggested rising levels of tetracycline-resistant gonorrhea may limit its effectiveness.
The study acknowledges that since the analysis was done at a single clinic its results “may have
limited generalisability to other non-sexual health-focused clinics or in different geographic
regions.”
Also, researchers did not measure antimicrobial resistance, a growing public health concern in
which overuse of antibiotics threatens the effectiveness of these medications.
News brief
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| 2 | A simple alert nearly triples the odds of chlamydia screening for young women, data show | 0 | 7.2 | 29-06-2026 |
| 3 | New research in antibiotic resistance | 0 | 10 | 24-01-2019 |
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| 6 | New prostate biopsy technique lowers infection risk | 5 | 7 | 19-09-2024 |
| 7 | WHO launches database to track sexually transmitted infections | 0 | 13.06 | 06-07-2026 |
| 8 | Antibiotic resistance is rising in invasive E coli found in US newborns, study finds | 0 | 6.4 | 04-05-2026 |
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| 10 | A surprising triple treatment completely clears hiv in newborn primates | 0 | 7.93 | 13-08-2026 |