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Спутники
РН
SpaceX
Роскосмос
NASA
СпутникиРНSpaceXРоскосмосNASARegulatory T cells (Tregs) can reverse inflammation in animal models. We conducted a randomized controlled clinical trial of Treg therapy in kidney transplant recipients with subclinical graft inflammation (NCT02711826). The primary endpoint was the change in graft inflammation on a follow-up biopsy 6 months after Treg infusion. The trial accrued 8 control group participants and 7 polyclonal Treg group participants; the latter received 400 × 106 to 1 × 109 polyclonally expanded Tregs without adverse events. Graft inflammation decreased substantially in both groups at 6 months; however, the degree of change was not significantly different between the groups. The peak of infused Tregs in circulation correlated positively with the pre-existing circulating CD4+ T cell numbers, suggesting that Treg engraftment was limited by the size of the endogenous CD4+ T cell compartment. Infused Tregs were detected in 14-day postinfusion biopsies, albeit...