I woke up to an email from a close friend of 25 years that his wife had passed away unexpectedly last night. She’d been fighting cancer for several years, had made progress, then had setbacks, and then made progress again. While I knew them both, I’d spent many hours over the years with my friend, so I immediately felt his sense of loss because I know how central his wife was to his life. I just hugged Amy and sent her out into the world for her day with tears in my eyes the phrase “In the end, entropy always wins.”

Last week, when another close friend died of cancer, Amy said to me “We fight the good fight our whole lives, and then we lose.” It wasn’t meant in a negative way but was an acknowledgment that in the end, we die.

Two other lines that always come to my mind in moments like this are “Life is a process of continuous oxidation” and “Life is a fatal disease.” The second is lodged particularly deep in my brain, as a friend told it to me after his child died at age 21.

While this applies to humans, it applies to everything else. I’ve yet to meet an immortal animal or plant. Many of the Built to Last companies have struggled or failed since Jim Collins wrote his iconic book. Granted, while Rome, which wasn’t built in a day, is still around, the Roman Empire had a finite life.

Companies don’t last forever. Institutions don’t last forever. Physical objects don’t last forever. Our planet won’t last forever. Human civilization won’t last forever.

In the end, entropy always wins. Consider that when you make decisions trying to control the outcome of something.