Posted: 13th September 2017

A group of computer scientists from the computational biology team lead by Blanca Rodriguez have published work which demonstrates that human In Silico drug trials can have higher levels of accuracy than animal models when predicting clinical pro-arrhythmic cardiotoxicity. The paper was lead by Elisa Passini.

Cardiotoxicity is one of the main causes of withdrawal during drug development, and identifying at early stages drugs that may cause adverse effects in specific human sub-populations is still a major challenge. Adverse effects can potentially lead to lethal arrhythmias, and are therefore a major cause of concern. Animal testing is limited in its use, and the continuing development of In Silico testing is key to better treatment in the future.

Read the whole journal article here: http://journal.frontiersin.org/article/10.3389/fphys.2017.00668/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Physiology&id=291794