Convicted “hell on wheels” killer Mackenzie Shirilla’s latest appeal for a new trial was rejected by the Ohio Supreme Court.

The legal blow to Shirilla — who’s serving 15 years to life for intentionally slamming her sedan into a building, killing her boyfriend and a close pal in July 2022 — was handed down Tuesday.

“Upon consideration of the jurisdictional memoranda filed in this case, the court declines to accept jurisdiction of the appeal,” read the ruling.

Mackenzie Shirilla’s latest appeal to receive a new trial was denied by the Ohio Supreme Court. NBC News

Shirilla was found guilty in 2023 on four counts of felonious assault and two counts of aggravated vehicular homicide, breaking down in tears as the judge called her “literal hell on wheels.”

Her first appeal for a new trial was also denied.

The 21-year-old’s lawyers argued in their latest appeal that Shirilla suffers from a “pre-existing medical condition” that could be to blame for her blacking out before the fatal wreck in northeast Ohio.

The killer’s attorneys argued that her past defense team failed to investigate or back up the alleged pre-existing condition with expert testimony. 

Shirilla, whose case was the focus of a hit Netflix documentary “The Crash,” is locked up at the Ohio Reformatory for Women for the fatal car wreck. 

The convicted “hell on wheels” killer suffered another legal blow as she is serving 15 years to life for crashing her car into a building, killing her boyfriend and a close pal in July 2022. A. Ripepi & Sons Funeral Home Shirilla was convicted in 2023 on the charge of double murder, with her lawyers discussing in their latest appeal that she has a “pre-existing medical condition” that led to the fatal wreck. City of Strongsville

She was just 17 when she crashed her car into a wall in Strongsville at 100 mph, killing her boyfriend Dominic Russo, 20, and 19-year-old friend Davion Flanagan.

Shirilla was the sole survivor of the crash. 

The killer just landed a new job serving chow at the Ohio penitentiary, where a former inmate claimed she prances around like a queen bee on “Mean Girls” and sports hickeys from prison hook-ups.

Her lawyers previously sought a new trial, filing the request on Oct. 24, 2024, one day past the deadline under the Ohio state law.

In May 2025, Cuyahoga County Judge Nancy Margaret Russo, the same judge who found Shiririlla guilty at her non-jury trial, ruled that the petition was invalid.

The Eighth Circuit Court of Appeals later ruled to uphold Russo’s decision.

Shirilla will be eligible for parole in October 2037.