Matthew McConaughey is an Oscar-winner who has racked up over 40 feature film roles since bursting onto the Hollywood scene in the early 1990s.

But the actor, 56, surprised fans by revealing the film that has continued to be his biggest money-maker in an interview with Entertainment Weekly on Thursday.

Instead of his career-defining role in Dallas Buyers Club (2013) or the sci-fi space epic Interstellar (2014), McConaughey revealed that his 2003 romantic comedy How to Lose a Guy in 10 Days is the 'gift that keeps on giving.'

He starred opposite Kate Hudson in the beloved film during his iconic 'rom-com' era in the early 2000s, which included roles in The Wedding Planner (2001), Failure to Launch (2006) and Ghosts of Girlfriends Past (2009).

'I think it's, probably, my favorite rom-com I've done, and a lot of people love that rom-com,' he told the outlet.

Despite How to Lose a Guy in 10 Days being released over two decades ago, McConaughey insisted that it still outperforms all of his other films in residuals.

'It still pays the best mailbox money of any film I've ever done. By far. By lengths,' he said. 

He also noted which month of the year he would see an increase in viewership, and therefore, earn more money pre-streaming. 

'When it used to be just DVDs or cable, every March I'd get a big check because Valentine's Day,' he recalled. 

'But, I mean, look, the movie for me, for that genre, let me just own that genre. How to Lose a Guy in 10 Days ... that's a real anchor in the rom-com genre through time,' he added.

McConaughey also compared the popularity of the romantic comedy to his 2013 film, The Wolf of Wall Street, and said portraying Mark Hanna (in his iconic chest-thumping scene) was 'a real launch-pad character.'

The movie star previously gushed about filming How to Lose a Guy in 10 Days with Hudson and reflected on their onscreen chemistry.

'I remember we met on the Paramount lot - I believe it was the time - and those casting sort of meeting couches, especially for rom-coms, you want to see the chemistry between the two leads,' he told The Hollywood Reporter in April 2024. 

'You want to see how the jive is,' he continued. 'We're not reading through the script. We're not reading lines.' 

He continued: 'Immediately, [Kate and I] were comfortable with each other and we jacked with each other, and we busted each other's chops, and we laughed a lot.

'There was a bit of rock and roll exchange, like, "Oh, this could be some heavyweight fun." And I think that's why I was cast, and that's why, for whatever extent, it worked.' 

Hudson shared the same sentiment in a Vanity Fair video in March 2025. 

'It was truly an amazing experience,' she said last year. 'And Matthew just brought it. And he always does.'

'With Matthew and I, it is just a very similar type of joie de vivre,' she continued. 

'We love life, we lead with energy, very competitive by nature, we're competitive with each other, very flirtatious, not afraid to be flirtatious,' she added.

'I think there's just a similar energy that somehow allowed us to be able to really connect onscreen and fall in love.' 

She also referred to him as one of the 'great loves' in her filmography. 

'I think that just is something that happens when you meet and you feel that chemistry,' she added. 'I feel really lucky that I got to experience that with someone as talented and as fun as Matthew.'