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Спутники
РН
SpaceX
Роскосмос
NASA
СпутникиРНSpaceXРоскосмосNASAApolipoprotein L1 (APOL1) is a human serum protein that acts as an innate immune defense against African trypanosomes, protecting against sleeping sickness (human African trypanosomiasis). Through evolutionary pressure, specific APOL1 gene variants (G1/G2) evolved in sub-Saharan Africa to counteract parasite resistance and are found almost exclusively in people of African or Caribbean heritage. However, the presence of 2 APOL1 alleles (G1/G1, G1/G2, or G2/G2) has shown a 51% increased risk for chronic kidney disease (CKD) and 2-fold increased risk of progression to kidney failure vs zero or 1 allele; increased risk is confined to 2 APOL1 alleles (high-risk genotype), with a kidney failure incidence of 35.22 per 100 person-years, vs 15.22 per 100 person-years and 12.69 per 100 person-years for 0 or 1 APOL1 allele, respectively. For potential living kidney donors, there is limited evidence to guide risk assessment for donation in the presence of 2 APOL1 alleles. Informing that need, in this issue of JAMA Internal Medicine, Hsu and colleagues from the APOL1 Long-Term Kidney Transplantation Outcomes Network present results from the Living Donor Extended Time Outcomes study. In this retrospective cohort study, previous living kidney donors (445 Black donors and 208 White donors) were contacted and invited to participate in a home-based research visit approximately 2 decades after donation. The critical finding is that Black kidney donors with 2 APOL1 alleles had considerably increased risk of developing an estimated glomerular filtration rate (eGFR) lower than 45 mL/min/1.73 m2 (relative risk, 2.31; 95% CI, 1.16-4.61) compared to Black kidney donors with 0 or 1 APOL1 allele. After adjusting for eGFR at time of donation, there remained statistically significant associations between APOL1 high-risk genotypes and higher risk of developing eGFR lower than 60 mL/min/1.73 m2 among Black kidney donors (relative risk, 1.50; 95% CI, 1.18-1.90).
| # | Наименование новости | Тональность | Информативность | Дата публикации |
|---|---|---|---|---|
| 1 | Apolipoprotein L1 Gene Genotype and Kidney Outcomes After Living Kidney Donation | 0 | 4.29 | 01-08-2026 |
| 2 | Some adverse pregnancy outcomes tied to kidney donation | 0 | 7 | 30-06-2026 |
| 3 | Evaluation of a Four-Year Blood Donation Practice at the University of Nigeria, Teaching Hospital (UNTH) [version 1; peer review: awaiting peer review] | 0 | 9.5 | 11-07-2026 |
| 4 | New-onset atrial fibrillation linked to faster eGFR decline | 0 | 7 | 23-06-2026 |
| 5 | Nearly half of kidney transplant patients never even get started | 0 | 6.69 | 01-07-2026 |
| 6 | MASH Comorbidity Burden and Overall, Waiting List, and Post–Liver Transplant Mortality | 0 | 8.64 | 05-08-2026 |
| 7 | APFED Opposes Proposed Federal Research Funding Rule; Urges Community Action | -5 | 6 | 19-06-2026 |
| 8 | Columbus twins closer than ever after kidney donation | 7 | 6 | 16-07-2026 |
| 9 | Antoine Johnson shines light on kidney disease with ‘Find Me A Match’ | 0 | 8.43 | 18-07-2026 |
| 10 | A silent kidney crisis is spreading far faster than experts expected | 0 | 8.41 | 29-05-2026 |