Sero-epidemiological studies of pathogen burden: A scoping review [version 3; peer review: 2 approved, 1 approved with reservations]

Дата публикации: 11-07-2026 05:37:37

Background Methodological advances in serological testing have made it feasible to quantify antibodies to multiple pathogens simultaneously. This has been used to study the impact of pathogen burden, i.e., cumulative lifetime exposure to persistent pathogens, on health and mortality outcomes. However, definitions for pathogen burden using serological data vary considerably. It is unclear how to best combine serological data for multiple pathogens for exposure/outcome definitions in epidemiological studies. Methods Following PRISMA-ScR guidelines, we conducted a scoping review of all relevant publications from MEDLINE, Embase, and Scopus until May 1st, 2025, with no language restrictions. We identified epidemiological studies defining pathogen burden, and which included at least three different pathogens. Results We included a total of 74 studies from 19 countries (published 2000–2025). Serology data from 50 different pathogens were analysed across all studies, with pathogen burden measured by combining a range of 3–17 pathogens across studies into a single metric. Approaches included counts of seropositive result, quantiles of antibody titres, and more complex statistical analyses to group pathogens. No study gave a clinical/scientific rationale for the approaches chosen. Conclusions Various analytical approaches have been used to define pathogen burden but there was limited justification for the chosen methodological approaches. More integrated approaches are needed for combining scientific and clinical knowledge of the interaction across different pathogens and epidemiological evidence into a meaningful measure of pathogen burden.

Схожие новости

#	Наименование новости	Тональность	Информативность	Дата публикации
1	Social and behavioural evidence for community protection in Public Health Emergencies: a scoping review and landscape analysis [version 1; peer review: awaiting peer review]	0	7.34	23-07-2026
2	Protocol for a scoping review and consensus process to describe and prioritise use cases for biomarkers and tests for tuberculosis [version 1; peer review: awaiting peer review]	0	5.16	13-07-2026
3	Living mapping review of global research funding for pandemic-prone infectious diseases– Pandemic PACT Grant Tracker [version 2; peer review: 2 approved with reservations]	0	8.06	06-07-2026
4	Integrated indicators for tracking climate mitigation and adaptation: a protocol for a rapid review with a focus on health co-benefits and trade-offs [version 2; peer review: 1 approved, 1 approved with reservations]	0	9.64	20-07-2026
5	Seroprevalence of neglected tropical diseases, arboviruses, vaccine-preventable diseases, and enteric protozoa from a national multi-pathogen serosurvey in Niue	0	7	16-07-2026
6	Integrating GIS and Genomics for AMR One Health Drug Target Discovery in Imipenem-Resistant Escherichia coli [version 3; peer review: 1 approved, 1 not approved]	0	12.09	10-07-2026
7	Exploring the evolution of multidrug resistance patterns in ESKAPEE pathogens using association mining: Key to antibiotic stewardship? [version 3; peer review: 3 approved with reservations]	0	10.12	17-07-2026
8	Scaling Lassa Virus Dynamics within Anthropogenic Ecosystems (SCAPES) Study Protocol: a mixed-methods observational cohort study of humans, rodents, and landscapes in Nigeria. [version 2; peer review: 1 approved, 2 approved with reservations]	0	12.1	28-07-2026
9	Association Between Routine Childhood Immunization Coverage and Under-Five Mortality in Sub-Saharan Africa: An Ecological Panel Study, 2000–2024	0	5	16-07-2026
10	A protocol for the TRACS-Liverpool study, tracking transmission of extended-spectrum beta-lactamase producing Enterobacterales across health and social care settings in the United Kingdom [version 1; peer review: 1 approved]	0	10.72	13-07-2026

Классификация: . Схожих патентов: 0. Схожих новостей: 10. Тональность: 0. Информативность: 8.98. Источник: wellcomeopenresearch.org.